Translational cancer research – a coherent cancer research continuum
نویسندگان
چکیده
منابع مشابه
Translational Cancer Research Program
Tumor microenvironment regulates cancer cell survival, metastasis, inflammation, and immune surveillance. There is growing evidence that the lymph node (LN) microenvironment, especially lymph node stromal cells (LNSCs), play a significant role in solid tumor growth, drug resistance, and subsequent extra-nodal metastasis of many types of cancer. A comprehensive understanding of the associated mo...
متن کاملTranslational research in breast cancer.
Translational research (TR) involves both the development of novel diagnostics and novel therapeutics. These two major developmental areas are often associated with each other and these associations often bring new paradigms in the management of cancer patients. For example, the development of trastuzumab-based treatments has been conducted in harmony with the development of new methodologies t...
متن کاملTranslational research in breast cancer.
routine. This also explains the interest of a larger public in these issues; breast cancer activists are willing to take up a role in the creation of biological and clinical databases. Patients are asked to lobby for and help in clinical studies. On the other hand, the access to human tissues is only possible via the patient. The discussion around the Human Tissue Act in Britain may serve as on...
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169: KRAS mutations in a population of patients operated for pancreatic adenocarcinoma [5] Researchers from Denmark presented a translational study on KRAS mutations in early pancreatic cancer. Previous reports had showed that the frequency of KRAS gene mutations in pancreatic cancer was as high as 75-90% [2]. This high percentage of KRAS mutations was representative of all pancreatic cancer st...
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Currently health services in Europe face the seemingly insurmountable challenge of funding trastuzumab (Herceptin) within their limited budgets for women with early stage breast cancer. Martine Piccart-Gebhart (Institute Jules Bordet, Brussels, Belgium) believes we would not now be confronting this huge financial burden had a translational research component been introduced upfront to trastuzum...
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ژورنال
عنوان ژورنال: Molecular Oncology
سال: 2019
ISSN: 1574-7891,1878-0261
DOI: 10.1002/1878-0261.12450